Mister Misery is looking to inflict maximum pain on Doctor Strange by attacking one of the Sorcerer Supreme's closest allies. Brace yourselves for the return of the dread Dormammu and the revenge of the evil Emprikul.

New York City is under attack by dark forces, and only Doctor Strange has a shot at saving it - but it's quite a long shot! And to have any hope, Strange must ally himself with some unsavoury people. No, not Spider-Woman - though the Doctor is recruiting her, too. We're talking about Wilson Fisk, A.K.A. the Kingpin. Together, they'll take the fight to the person running New York City - Baron Mordo! But even if they win, are they ready for the Hydra-occupied...

After the Empirikul destroyed almost all the world's magic and nearly killed Doctor Strange, the Sorcerer Supreme must try and build himself back up. Plus, witness the return of Baron Mordo! But what effect did the Empirikul attack have on him?

An ancient evil threatens to unravel the fabric of reality, and one Sorcerer Supreme may not be enough. Doctor Strange must unite past, present and future Sorcerers Supremes to stem the coming darkness - Merlin, the Ancient One, Wiccan and more! But Strange should watch his back, not all of these Sorcerers have his best interests in mind.

Doctor Strange and The Masked Raider gather a non-team of Marvel's weirdest, wildest heroes for a mission that will uncover the hidden architecture of reality itself! This cosmos was not the first to exist ... but, if the Defenders can't track Marvel's oldest villain through the deepest trenches of time, it might be the last! The group must travel to the long-extinct previous cosmos, the birthplace of Galactus - but the Devourer is not the man they...