When mercenary Wade Wilson learned that he was dying of cancer, he signed up as a test subject for the mysterious Weapon X program. Wade's cancer was arrested via the implanting of a healing factor derived from the mutant known as Wolverine. However, Wilson soon found himself the victim of the cruel experiments of the vile Doctor Killebrew, where he escaped and, assuming the name Deadpool, embarked on a life as an assassin.

What dark technology from the secret recesses of S.H.I.E.L.D. could power an army of LMD-eadpools? It's a blast from the past - meanwhile, in the future, Old Man Parker makes a decision that alters our present! The Master Matrix is unearthed, and at the heart of its history are Mary and Richard Parker, A.K.A. the Amazing Spider-Parents! Just when you thought you could trust that two people were without blemish, Deadpool somehow ruins them, too. But...

Nothing will ever be the same after this! NOTHING! Spider-Man and Deadpool just BARELY make it back from the Negative Zone in the middle of an Event that the Marvel U's heroes have already lost.