When mercenary Wade Wilson learned that he was dying of cancer, he signed up as a test subject for the mysterious Weapon X program. Wade's cancer was arrested via the implanting of a healing factor derived from the mutant known as Wolverine. However, Wilson soon found himself the victim of the cruel experiments of the vile Doctor Killebrew, where he escaped and, assuming the name Deadpool, embarked on a life as an assassin.

The adventures of your favorite duo in comic books continue, and this time Spider-Man and Deadpool have decided not to be funny anymore?! What could have possibly driven our two heroes to take the funny outta their own funny book? And just what the heck has Slapstick got to do with it?! When the villainous Arcade decides to build a second, even deadlier Murderworld in Madripoor, he kidnaps Spider-Man and forces him to be the park's first guest!

Things seem weird, even by Deadpool's standards, when Matt 'Daredevil' Murdock offers him a profitable - nay, straightforward! - contract. No chaos, no unpredictability, no funny business. C'mon, Murdock, that's just not Deadpool's style. Sensing something is up, Deadpool grabs an innocent bystander off the street to confuse any semblance of predictability the universe is trying to force on him. Good-hearted mischief spirals into a sinister plot full...